Treatment for Syphilis: Misused Medicines

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The most effective drug to treat syphilis is benzathine Penicillin G, which should always be administered as an injection and the dose varies according to the phase of the illness.

In case of allergy to this drug, other antibiotics such as tetracycline, erythromycin or ceftriaxone can be used, but penicillin is the most effective drug always with the first choice. Before trying another antibiotic, you should opt for penicillin desensitization so that the treatment can be successful with this same drug. The desensitization consists of applying small doses of penicillin until the body cannot refuse this medication.

The treatment schedule must be according to the doctor’s guidelines, but it can be:

Phases of illness dose of penicillin other medicines
primary syphilis 1 injection Benzathine Penicillin G of 2,400,000IU.

Doxycycline, 100 mg twice a day or

Tetracycline, 500 mg 4x/day or both for 14 days

secondary syphilis

2 injections of 1,200,000 IU of Benzathine Penicillin G in different regions of the body.

Doxycycline, 100 mg twice a day or
Tetracycline, 500 mg 4x/day or both for 14 days
tertiary syphilis 3 injections of penicillin with 2,400,000 IU in different regions of the body, with an interval of 7 days between each dose Doxycycline, 100 mg twice a day or
tetracycline, 500 mg 4x/day, both
for 28 days
neurosyphilis 6 daily injections of Penicillin G Crystalline with 2 to 4 million for 10-14 days Procaine Penicillin, 2.4 million
IU/IM/day, + Probenecid
500 mg/PO/4x/day or both for 14 days
Congenital syphilis

Penicillin G Crystalline 100 to 150 thousand
IU/kg/EV/day, in 2 doses in the first week of life or in 3 doses in babies between 7 and 10 days;
Penicillin G Procaine 50 thousand IU/kg/IM, once a day for 10 days;

Benzathine penicillin G** 50 thousand IU/kg/IM,
single dose

not indicated
Syphilis in the embarazo Penicillin G Benzathine Erythromycin Stearate 500
mg orally, 6/6 hours for 10 days
or until reaching the cure

Try to find out if you are allergic to penicillin

The way to know if the person is allergic to penicillin is to float a small amount of this drug in the skin and observe if the region presents some reaction signal such as reddening or comession. If these signs are present, the person has an allergy.

This task must be carried out by a nurse in the hospital and is generally carried out on the forearm.

How to desensitize penicillin

Desensitization to penicillin is indicated in case of allergy to this drug, especially in case of treatment for syphilis in embarazo and treatment of neurosyphilis. This procedure must be carried out in the hospital, being the use of tablets in the most secure way.

There is no indication for the use of antihistamines or steroids before starting penicillin, since these drugs do not prevent the reaction of anaphylaxis and can better hide the first signs, delaying the treatment.

After the procedure, treatment with penicillin should be started. If the person spends more than 28 days without any contact with this medicine, it will be necessary to check again if there are signs of allergy and if they are present, the desensitization should be started again.

Common reactions to penicillin

After the injection, symptoms such as fever, chills, headache, pain in the muscles and in the joints can arise that can appear from 4 to 24 hours after the injection. To control these symptoms, the doctor may recommend taking an analgesic or an antipyretic.

When penicillin is contraindicated

The treatment for syphilis cannot be treated with penicillin in the case of Stevens-Johnson, toxic epidermal necrolysis and exfoliative dermatitis. In these cases, the treatment for syphilis must be carried out with other antibiotics.

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Consult a Doctor | Translated by User2937

Content for educational purposes only

The translator user relied on the following text:

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Disclaimer – (English version>) This content has been prepared based on information from research, additional publications, or the translation/verification work of a volunteer editor of this web council. This is a non-profit service. It is strongly recommended that all details and information published be carefully verified. We never allow medication recommendations, medication package inserts or any medication guidance. We never allow partisan politics as information.

Isenção de responsabilidade – (versão em português): Este conteúdo foi preparado com base em informações de pesquisas, publicações adicionais ou no trabalho de tradução/verificação de um editor voluntário deste conselho web. Este é um serviço sem fins lucrativos. É altamente recomendável que todos os detalhes e informações publicadas sejam verificadas cuidadosamente. Nunca permitimos recomendações de medicamentos, bulas ou qualquer orientação sobre medicamentos. Nunca permitimos a política partidária como base para checagem. Para mais informações, leia nossos termos.

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